“Opinion” is the operative word in your question, Oral. Both share similar weather, but Quito is four times bigger than Cuenca so it has more of everything–good and bad. I live in Cuenca and love our city’s manageable size, yet I’ve grown to enjoy the energy and especially the greater choice of excellent cuisine in Quito. There is little mention of the number of expats in Quito (although I suspect it’s more than you’d think), and the best guess is there are several thousand now in Cuenca.